The Impact of Biotechnology on Reproductive Medicine

The Impact of Biotechnology on Reproductive Medicine

David Roy Meldrum 1 , *

Author Information

1 Department of Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, University of California San Diego, La Jolla, U.S.A.
Article information
  • Biotechnology and Health Sciences: February 2017, 4 (1); e13433
  • Published Online: December 12, 2016
  • Article Type: Editorial
  • Received: October 30, 2016
  • Accepted: November 16, 2016
  • DOI: 10.5812/bhs.13433

To Cite: Roy Meldrum D. The Impact of Biotechnology on Reproductive Medicine, Biotech Health Sci. 2017 ;4(1):e13433. doi: 10.5812/bhs.13433.

Copyright © 2016, Qazvin University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. Hollands P. Differentiation of embryonic haemopoietic stem cells from mouse blastocysts grown in vitro. Development. 1988; 102(1): 135-41[PubMed]
  • 2. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med. 1992; 326(2): 90-4[DOI][PubMed]
  • 3. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med. 1998; 338(20): 1397-404[DOI][PubMed]
  • 4. Meldrum DR, Gambone JC, Morris MA, Ignarro LJ. A multifaceted approach to maximize erectile function and vascular health. Fertil Steril. 2010; 94(7): 2514-20[DOI][PubMed]
  • 5. Meldrum DR, Burnett AL, Dorey G, Esposito K, Ignarro LJ. Erectile hydraulics: maximizing inflow while minimizing outflow. J Sex Med. 2014; 11(5): 1208-20[DOI][PubMed]
  • 6. Soares SR, Gomez R, Simon C, Garcia-Velasco JA, Pellicer A. Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome. Hum Reprod Update. 2008; 14(4): 321-33[DOI][PubMed]
  • 7. Gardner DK, Lane M, Schoolcraft WB. Physiology and culture of the human blastocyst. J Reprod Immunol. 2002; 55(1-2): 85-100[PubMed]
  • 8. Gardner DK, Meseguer M, Rubio C, Treff NR. Diagnosis of human preimplantation embryo viability. Hum Reprod Update. 2015; 21(6): 727-47[DOI][PubMed]
  • 9. Schmid TE, Eskenazi B, Baumgartner A, Marchetti F, Young S, Weldon R, et al. The effects of male age on sperm DNA damage in healthy non-smokers. Hum Reprod. 2007; 22(1): 180-7[DOI][PubMed]
  • 10. de La Rochebrochard E, de Mouzon J, Thepot F, Thonneau P, French National IA. Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France. Fertil Steril. 2006; 85(5): 1420-4[DOI][PubMed]
  • 11. Jin J, Pan C, Fei Q, Ni W, Yang X, Zhang L, et al. Effect of sperm DNA fragmentation on the clinical outcomes for in vitro fertilization and intracytoplasmic sperm injection in women with different ovarian reserves. Fertil Steril. 2015; 103(4): 910-6[DOI][PubMed]
  • 12. Mahfouz R, Sharma R, Thiyagarajan A, Kale V, Gupta S, Sabanegh E, et al. Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species. Fertil Steril. 2010; 94(6): 2141-6[DOI][PubMed]
  • 13. Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl. 2005; 26(3): 349-53[DOI][PubMed]
  • 14. Greco E, Scarselli F, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, et al. Efficient treatment of infertility due to sperm DNA damage by ICSI with testicular spermatozoa. Hum Reprod. 2005; 20(1): 226-30[DOI][PubMed]
  • 15. Brewis A, Meyer M. Marital coitus across the life course. J Biosoc Sci. 2005; 37(4): 499-518[PubMed]
  • 16. Safarinejad MR. Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. Andrologia. 2011; 43(1): 38-47[DOI][PubMed]
  • 17. Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, et al. In vitro fertilization with preimplantation genetic screening. N Engl J Med. 2007; 357(1): 9-17[DOI][PubMed]
  • 18. Werner MD, Scott RJ, Treff NR. 24-chromosome PCR for aneuploidy screening. Curr Opin Obstet Gynecol. 2015; 27(3): 201-5[DOI][PubMed]
  • 19. Meldrum DR, Su HI, Katz-Jaffe MG, Schoolcraft WB. Preimplantation genetic screening 2.0: an evolving and promising technique. Fertil Steril. 2016; 106(1): 64-5[DOI][PubMed]
  • 20. Meldrum DR. Lightening the burden of care in assisted reproductive technology. Fertil Steril. 2016; 105(5): 1144-5[DOI][PubMed]
  • 21. Donnez J, Hudecek R, Donnez O, Matule D, Arhendt HJ, Zatik J, et al. Efficacy and safety of repeated use of ulipristal acetate in uterine fibroids. Fertil Steril. 2015; 103(2): 519-27 e3[DOI][PubMed]
  • 22. Kim SM, Lee M, Lee SY, Park E, Lee SM, Kim EJ, et al. Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist. J Med Chem. 2016; 59(19): 9150-72[DOI][PubMed]
  • 23. Haouzi D, Assou S, Mahmoud K, Tondeur S, Reme T, Hedon B, et al. Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients. Hum Reprod. 2009; 24(6): 1436-45[DOI][PubMed]
  • 24. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril. 2011; 96(2): 344-8[DOI][PubMed]
  • 25. Simon C, Vladimirov IK, Castillon Cortes G, Ortega I, Cabanillas S, Vidal C, et al. Prospective, randomized study of the endometrial receptivity analysis (ERA) test in the infertility work-up to guide personalized embryo transfer versus fresh transfer or deferred embryo transfer. Fertil Steril. 2016; 106(3): 46-7[DOI]
  • 26. Oktay KH, Pacheco FS. Current succes and efficiency of autologous ovarian transplantation with cryopreserved tissue: a meta-analysis. Fertil Steril. 2016; 106(3): 131-2[DOI]
  • 27. Kawamura K, Cheng Y, Suzuki N, Deguchi M, Sato Y, Takae S, et al. Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc Natl Acad Sci U S A. 2013; 110(43): 17474-9[DOI][PubMed]
  • 28. Mohamed SA, Shalaby SM, Brakta S, Stone L, Ellakany M, Al-Hendy A. Umbilical cord blood mesenchymal stem cells as an infertility treatment for chemotherapy induced premature ovarian failure. Fertil Steril. 2016; 106(3): 128[DOI]
  • 29. Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015; 14(5): 887-95[DOI][PubMed]
  • 30. Bentov Y, Hannam T, Jurisicova A, Esfandiari N, Casper RF. Coenzyme Q10 Supplementation and Oocyte Aneuploidy in Women Undergoing IVF-ICSI Treatment. Clin Med Insights Reprod Health. 2014; 8: 31-6[DOI][PubMed]
  • 31. Fragouli E, Spath K, Alfarawati S, Kaper F, Craig A, Michel CE, et al. Altered levels of mitochondrial DNA are associated with female age, aneuploidy, and provide an independent measure of embryonic implantation potential. PLoS Genet. 2015; 11(6)[DOI][PubMed]
  • 32. Diez-Juan A, Rubio C, Marin C, Martinez S, Al-Asmar N, Riboldi M, et al. Mitochondrial DNA content as a viability score in human euploid embryos: less is better. Fertil Steril. 2015; 104(3): 534-41 e1[DOI][PubMed]
  • 33. Hayashi K, Ogushi S, Kurimoto K, Shimamoto S, Ohta H, Saitou M. Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice. Science. 2012; 338(6109): 971-5[DOI][PubMed]
  • 34. Zhou Q, Wang M, Yuan Y, Wang X, Fu R, Wan H, et al. Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. Cell Stem Cell. 2016; 18(3): 330-40[DOI][PubMed]
  • 35. Hendriks S, Dancet EA, van Pelt AM, Hamer G, Repping S. Artificial gametes: a systematic review of biological progress towards clinical application. Hum Reprod Update. 2015; 21(3): 285-96[DOI][PubMed]