The Effect of Myricetin Flavonoid on the Expression of Fyn Gene in Melanoma Cells (A375)

Fereshte Abdolmaleki 1 ,
Sahar Moghbelinejad 2
and
Hossein Ahmadpour-Yazdi 2 , *

Authors Information

1 Student Research Committee of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran
2 Cellular and Molecular Research Center, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Article information
  • Biotechnology and Health Sciences: February 2018, 5 (1); e14484
  • Published Online: October 14, 2017
  • Article Type: Research Article
  • Received: June 3, 2017
  • Revised: July 25, 2017
  • Accepted: September 20, 2017
  • DOI: 10.5812/bhs.14484

To Cite: Abdolmaleki F, Moghbelinejad S, Ahmadpour-Yazdi H. The Effect of Myricetin Flavonoid on the Expression of Fyn Gene in Melanoma Cells (A375), Biotech Health Sci. 2018 ; 5(1):e14484. doi: 10.5812/bhs.14484.

Abstract
Copyright © 2017, Biotechnology and Health Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
Footnote
References
  • 1. Gandhi SA, Kampp J. Skin Cancer Epidemiology, Detection, and Management. Med Clin North Am. 2015;99(6):1323-35. doi: 26476255].
  • 2. Jaime A, Remsberg CM, Takemoto JK, Vega-Villa KR, Andrews PK, Sayre CL, et al. Polyphenols and flavonoids : an overview. Flavonoid Pharmacokinetics: Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, And Toxicology. 2013.
  • 3. Pinheiro PF, Justino GC. Structural analysis of flavonoids and related compounds-a review of spectroscopic applications. INTECH Open Access Publisher; 2012.
  • 4. Ramos S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem. 2007;18(7):427-42. doi: 17321735].
  • 5. Yao Y, Lin G, Xie Y, Ma P, Li G, Meng Q, et al. Preformulation studies of myricetin: a natural antioxidant flavonoid. Pharmazie. 2014;69(1):19-26. [PubMed: 24601218].
  • 6. Shih YW, Wu PF, Lee YC, Shi MD, Chiang TA. Myricetin suppresses invasion and migration of human lung adenocarcinoma A549 cells: possible mediation by blocking the ERK signaling pathway. J Agric Food Chem. 2009;57(9):3490-9. doi: 19326946].
  • 7. Ying X, Chen X, Feng Y, Xu HZ, Chen H, Yu K, et al. Myricetin enhances osteogenic differentiation through the activation of canonical Wnt/beta-catenin signaling in human bone marrow stromal cells. Eur J Pharmacol. 2014;738:22-30. doi: 24876056].
  • 8. Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, et al. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell. 2000;6(4):909-19. doi: 11090628].
  • 9. Young MR, Yang HS, Colburn NH. Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4. Trends Mol Med. 2003;9(1):36-41. doi: 12524209].
  • 10. Chan KS, Sano S, Kiguchi K, Anders J, Komazawa N, Takeda J, et al. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest. 2004;114(5):720-8. doi: 15343391].
  • 11. Boggon TJ, Eck MJ. Structure and regulation of Src family kinases. Oncogene. 2004;23(48):7918-27. doi: 15489910].
  • 12. Čalić, M , Jelić, D , Antolović, R , Nujić, K , Marjanović, N , Stupin Polančec, D , et al. Flavonoids as inhibitors of lck and fyn kinases. Croat Chem Acta. 2005;78(3):367-74.
  • 13. Posadas EM, Al-Ahmadie H, Robinson VL, Jagadeeswaran R, Otto K, Kasza KE, et al. FYN is overexpressed in human prostate cancer. BJU Int. 2009;103(2):171-7. doi: 18990162].
  • 14. Chen R, Kim O, Yang J, Sato K, Eisenmann KM, McCarthy J, et al. Regulation of Akt/PKB activation by tyrosine phosphorylation. J Biol Chem. 2001;276(34):31858-62. doi: 11445557].
  • 15. Liao Y, Grobholz R, Abel U, Trojan L, Michel MS, Angel P, et al. Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer. Int J Cancer. 2003;107(4):676-80. doi: 14520710].
  • 16. Vernon AE, LaBonne C. Tumor metastasis: a new twist on epithelial-mesenchymal transitions. Curr Biol. 2004;14(17):R719-21. doi: 15341765].
  • 17. Abdolmaleki F, Gheibi N, Ahmadpour_ Yazdi H. The inhibitory effect of myricetin in melanoma cells (A375). Novelty Biomed. 2017;5(3):104-8.
  • 18. Pfaffl MW. A-Z of Quantitative PCR. International University Line (IUL); 2004.
  • 19. Gajos-Michniewicz A, Czyz M. Modulation of WNT/beta-catenin pathway in melanoma by biologically active components derived from plants. Fitoterapia. 2016;109:283-92. doi: 26851176].
  • 20. Yadav V, Denning MF. Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. Mol Carcinog. 2011;50(5):346-52. doi: 21480388].
  • 21. Zhang X, Li F, Zhu PL. Fyn-related kinase expression predicts favorable prognosis in patients with cervical cancer and suppresses malignant progression by regulating migration and invasion. Biomed Pharmacother. 2016;84:270-6. doi: 27665472].
  • 22. Berwanger B, Hartmann O, Bergmann E, Bernard S, Nielsen D, Krause M, et al. Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma. Cancer Cell. 2002;2(5):377-86. doi: 12450793].
  • 23. Chen JS, Hung WS, Chan HH, Tsai SJ, Sun HS. In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics. 2013;29(4):420-7. doi: 23267173].
  • 24. Goel RK, Lukong KE. Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology. Cancer Metastasis Rev. 2016;35(2):179-99. doi: 27067725].
  • 25. Devi KP, Rajavel T, Habtemariam S, Nabavi SF, Nabavi SM. Molecular mechanisms underlying anticancer effects of myricetin. Life Sci. 2015;142:19-25. doi: 26455550].
  • 26. Jung SK, Lee KW, Byun S, Kang NJ, Lim SH, Heo YS, et al. Myricetin suppresses UVB-induced skin cancer by targeting Fyn. Cancer Res. 2008;68(14):6021-9. doi: 18632659].
  • 27. Li Y, Cui SX, Sun SY, Shi WN, Song ZY, Wang SQ, et al. Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APCMin/+ mice. Oncotarget. 2016;7(37):60446-60. doi: 27507058].
  • 28. Huang H, Chen AY, Ye X, Li B, Rojanasakul Y, Rankin GO, et al. Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway. Int J Oncol. 2015;47(4):1494-502. doi: 26315556].
  • 29. Bagu ET, Miah S, Dai C, Spriggs T, Ogunbolude Y, Beaton E, et al. Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation. Oncotarget. 2017;8(7):11442-59. doi: 28077797].
  • 30. Hou DX, Kumamoto T. Flavonoids as protein kinase inhibitors for cancer chemoprevention: direct binding and molecular modeling. Antioxid Redox Signal. 2010;13(5):691-719. doi: 20070239].
  • 31. Bogoyevitch MA, Fairlie DP. A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding. Drug Discov Today. 2007;12(15-16):622-33. doi: 17706543].
  • 32. McCubrey JA, Rakus D, Gizak A, Steelman LS, Abrams SL, Lertpiriyapong K, et al. Effects of mutations in Wnt/beta-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer. Biochim Biophys Acta. 2016;1863(12):2942-76. doi: 27612668].
  • 33. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006;127(3):469-80. doi: 17081971].